2007 Detroit Lions Schedule
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| Date | Opponent |
Location | Time (ET) | Result |
| 9/9 | @ Oakland Raiders | McAfee Coliseum | 4:15pm | W 36-21 |
| 9/16 | Minnesota Vikings | Ford Field | 4:05pm | W 20-17 OT |
| 9/23 | @ Philadelphia Eagles | Lincoln Financial Field | 1:00pm | L 56-21 |
| 9/30 | Chicago Bears | Ford Field | 1:00pm | W 37-27 |
| 10/7 | @ Washington Redskins | FedEx Field | 1:00pm | L 34-3 |
| 10/14 | Bye | |||
| 10/21 | Tampa Bay Bucaneers | Ford Field | 1:00pm | W 23-16 |
| 10/28 | @ Chicago Bears | Solider Field | 1:00pm | W 16-7 |
| 11/4 | Denver Broncos | Ford Field | 1:00pm | W 44-7 |
| 11/11 | @ Arizona Cardinals | University of Phoenix | 4:15pm | L 31-21 |
| 11/18 | New York Giants | Ford Field | 4:15pm | L 16-10 |
| 11/22 | Green Bay Packers | Ford Field | 12:30pm | L 37-26 |
| 12/2 | @ Minnesota Vikings | The Metrodome | 1:00pm | L 42-10 |
| 12/9 | Dallas Cowboys | Ford Field | 1:00pm | L 28-27 |
| 12/16 | @ San Diego Chargers | Qualcomm Stadium | 4:15pm | L 51-14 |
| 12/23 | Kansas City Cheifs | Ford Field | 1:00pm | W 25-20 |
| 12/30 | @ Green Bay Packers | Lambeau Field | 1:00pm | L 34-13 |
